THEY WERE WRONG: Authors retract study alleging hydroxychloroquine was too dangerous for COVID-19 patients

@Nan G: Anyone with a shred of intelligence could understand that there was fraud in this study. Millions of people had been taking hydroxychloroquine with out the side effects that were being described by the media and the FDA. More millions had been taking chloroquine with similar results. Thousands of health providers were also taking hydroxychloroquine and stock piling quantities for their families to prevent them from getting the virus.

It is also apparent that Trump Resisters killed hundreds, maybe thousands of people to try to make the President look silly. Thousands of scientists and the World Health Organization violated their ethical responsibilities as a scientists or health providers to support their political views. The people of the World can no longer have confidence in those hypocritical people. Licensing bureaus should remove their licenses to practice medicine . A country or World that must rely upon a body of scientists and health care providers with out ethics has no health care program.

OH! how the liberals and their media were dancing in the streets over this “study! They were ecstatic because Trump had said HCQ was promising and, then, that he was taking it. “Oh, look how stupid Trump is!! First, drink bleach and now THIS!!”

Dumbasses of their own construction. They are a hazard to themselves and others. Trump, again: RIGHT. Liberals, again:WRONG. Don’t they ever get tired of getting their asses kicked?

@Randy: Hey… THEY believe in science… everyone else denies science. Of course, their interpretation of “science” is some words some half-witted hack puts together which EVERY sycophantic lemming will leap upon like a dog licking up bacon grease.

Here’s one of the most recent studies. The conclusions are not based on a randomly collected medical reports. The conclusions are based on a carefully controlled clinical study, where a comparison was made between two large groups of hospitalized COVID-19 patients. The only difference between the two groups was that the patients in one received hydrochloriquine in conjunction with a full range of hospital care and support, while the patients in the second did not.

Hydrochloroquine treatment provided zero benefit. In fact, those were treated with it were 11 percent more likely to die. While 11 percent higher fatality rate was considered statistically insignificant in the context of a single clinical trial, it definitely can’t be taken as an indicator of safety.

The bottom line here would be possibly safe, but very likely ineffective.

The main problem with the hydrochloroquine cures COVID-19 pitch is that the motivation was political, not medical. It was used to help break down social distancing measures so consumers would more quickly get out there to resume spending, and workers would more quickly get out there to resume working.

June 5, 2020 – Study: Hydroxychloroquine had no benefit for hospitalized Covid-19 patients, possibly closing door to use of drug

A major clinical trial showed the malaria drug hydroxychloroquine had no benefit for patients hospitalized with Covid-19, likely closing the door to the use of the highly publicized medicine in the sickest patients — a use for which it was widely prescribed as the pandemic hit the U.S.

The results come from a study called RECOVERY, funded by the U.K. government, that sought to randomly assign large numbers of patients to multiple potential treatments in the country’s National Health Service. The goal was to rapidly get answers as to what worked and what didn’t.

“Today’s preliminary results from the RECOVERY trial are quite clear – hydroxychloroquine does not reduce the risk of death among hospitalized patients with this new disease,” University of Oxford epidemiologist Martin Landray, one of the study’s leaders, said in a statement. “This result should change medical practice worldwide and demonstrates the importance of large, randomized trials to inform decisions about both the efficacy and the safety of treatments.”

A total of 1,542 received hydroxychloroquine, and 3,132 received usual care. After 28 days of treatment, 25.7% of those on hydroxychloroquine and 23.5% of those received usual care had died, meaning those on hydroxychloroquine were 11% more likely to die. That difference was not statistically significant.

There was “no beneficial effect” on how long patients stayed in the hospital, or on other outcomes.

The results were shared via a press release, which the study’s lead authors shared on Twitter. They have not been peer-reviewed or published in a medical journal. The researchers said that full results would be shared as soon as possible.

Still, experts said even the top-line results showed they were meaningful.

“This is a hugely important finding that will likely end use of the drug in hospitalized Covid patients, given the other existing data as well,” said Walid Gellad, director of the Center for Pharmaceutical Policy and Prescribing at the University of Pittsburgh. Gellad said that he is curious to see the results of other ongoing studies, and that it is still an open question whether the medicine might work earlier in the disease. “We need real answers there as well,” he said.

Robert Califf, the former Food and Drug Administration commissioner and Alphabet employee, tweeted that the study “essentially rules out benefit of [hydroxychloroquine] in critically ill hospitalized patients.” He wrote that the results showed “no benefit; no major risk.”

In addition to being used for malaria, hydroxychloroquine is prescribed to treat conditions including rheumatoid arthritis and lupus. But it was known to increase the risk of arrhythmias.

The FDA still authorized emergency use of the drug in hospitalized patients in March, citing the possible safety issues.

Concerns were heightened by a May 22 study in British medical journal the Lancet. That study, which claimed to use a database from hundreds of hospitals around the world, seemed to indicate that treatment with hydroxychloroquine increased the death rate and the rate of arrhythmias.

But on Thursday, the Lancet retracted that study at the request of the authors after widespread questions about the database the study used and the company, Surgisphere, that had provided it. The authors not associated with Surgisphere had asked for the data to be audited, and Surgisphere refused. As such, they wrote, “we can no longer vouch for the veracity of the primary data sources.”

On Wednesday, another group of researchers released results from another randomized study, testing whether giving people hydroxychloroquine shortly after they have been exposed to someone with Covid-19 could prevent disease transmission. That study also showed no benefit, thought some researchers, including Gellad and Califf, say some effect is still possible.

“It could still have an effect given very early in disease, although less and less likely every day that passes,” Gellad said.

There are dozens of studies ongoing with hydroxychloroquine, more than for any other potential Covid-19 treatment, including studies that combine it with antibiotics such as azithromycin or doxycycline. But the results appear to show the benefit of putting resources into testing medicines in large randomized trials, the medical gold standard, during a pandemic.

The RECOVERY trial represented an early and large effort at such studies, testing not only hydroxychloroquine but also a pair of HIV drugs, lopinavir and ritonavir, and the steroid dexamethasone. The study was later expanded to also test using plasma from recovered patients to treat those who are still ill.

@Greg:
Greg, if you go to the link for the actual study, (35 page pdf) you will see why Randy in #7 is correct.
It’s a bad study for this drug.
What were the outcomes they EXPECTED in this study?
The participants were so sick that they were ONLY these:
Death, need for ventilation and need for
renal replacement therapy.
Pretty sick puppies.
HCQ is supposed to be used after EXPOSURE but before any symptoms.
Not after showing really bad symptoms!

@Greg: You really are a rock head greggie. Specific procedures need to be followed when a test is being performed IAW with scientific procedures. No one ever said it was a miracle drug. The proponents said it was an inexpensive solution to prevention and minimizing initial symptoms. When you wait to treat someone on their last gasps of life, nothing rarely helps. It is quite obvious that you have no knowledge about scientific processes and the procedures that are necessary to determine effectiveness of a drug. You only believe in consensus and the consensus here is you are a rock.

I understand better than you seem to believe. Why anyone would think mainstream news outlets are providing fake news about the COVID-19 pandemic is beyond me. A false sense of security may turn out to be a greater danger to the economy than excessive caution.

June 5, 2020 – Florida Sets New Single-Day Record for Coronavirus Cases Since Reopening Economy, Over 4,000 in Three Days

@Greg: It’s over. It’s done. The cover is yanked off. A politically motivated bogus “study” was cobbled together to try and show Trump was wrong. It failed. “The Lancet”, like the NYT, CNN, MSNBC, ABC, CBS, NBC and others, jumped on this study without wondering if it was worth the paper it was printed on. A little too anxious to get that “bombshell”. Then all the other propaganda outlets took off a-runnin’ with it as well.

All made fools of. All made to look totally stupid. Well, we tried to tell you, didn’t we? How many told you, “But, it’s WORKING. Doctors prescribe it because it works. People recover from COVID19 because it works.” But you thought you had that bombshell.

When will you people learn? When are you going to realize and finally admit you are JUST WRONG?

Why anyone would think mainstream news outlets are providing fake news about the COVID-19 pandemic is beyond me.

No it isn’t. You know exactly why. Your propaganda outlets don’t report anything that is not designed to undercut Trump. In this case, it was intended to simply be a minor embarrassment; Trump says HCQ is good, this “study” says he’s stupid. It all blew right up in your ignorant faces. Wash it off… quickly. Black face is not looked kindly upon anymore, no matter what the excuse.

@Greg: But he took the advice of his doctor greggie the rock! You just can not help but be a loser. Has that been the story of your life?

You can’t find any credible medical evidence demonstrating that hydroxychloroquine is effective at preventing or treating COVID-19 disease, because there’s no such evidence to be found.

Go ahead. Try to find some. See what you come up with. And remember, credible is the word that counts. B.S. assertions without legitimate statistical evidence behind them are a dime a dozen. They mean nothing.

@Deplorable Me: greggie the rock still puts his pulled teeth under the pillow at night!

@Greg: Your self-sustained willful ignorance is not my problem. I have and seen people actually testify to its benefits.

@Greg:

I’ve seen people testifying that some televangelist has remotely cured them of the palsy, or made a thousand dollars miraculously turn up in their mail box

And then there is the Democrat Party that has been selling snake oil to minorities since 1965.

Again, cowardly Comrade Greggie, tell us what the Democrats have done for blacks EVAH. Or will you just tell me to F myself again since you really can’t list anything?

@Greg:

I’m not black, so it isn’t my place to speak for any black person. Nor yours. Like anyone else, they can and will make up their own minds who they want to vote for.

Comrade Greggie, ever the cowardly weasel.

@Greg:

’m not black, so it isn’t my place to speak for any black person. Nor yours. Like anyone else, they can and will make up their own minds who they want to vote for.

They’ll vote for who the Democrat elite WANT them to vote for or the Democrat elite will change their vote to the “proper” vote.